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   2014| June  | Volume 5 | Issue 1  
    Online since December 21, 2017

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Rhesus incompatibility amongst child-bearing women in Ile-Ife, South Western Nigeria
RA Bolarinwa, KO Ajenifuja, AA Oyekunle, WO Ismail
June 2014, 5(1):35-39
Background: Rhesus (Rh) isoimmunisation is a recognized cause of perinatal mortality and is also a risk factor for neonatal jaundice. It occurs exclusively in parous RhD negative women with at least one prior pregnancy or in women with previous transfusion of incompatible Rh blood irrespective of their parity. Record on the prevalence of Rh negative pregnant women and the incidence and significance of isoimmunisation on pregnancies is sparse in our setting. This study attempts to provide an insight report on pregnancy outcome in Rh negative Nigerian women. Materials and Methods: The blood bank record of all pregnant women from January 2003 to December 2007 was reviewed for their ABO and Rh blood group. All those that were Rh negative and had their deliveries at the Obafemi Awolowo University Teaching hospitals Complex, Ile-Ife had their clinical case notes reviewed for the outcome of their pregnancies. Results: A total of 2159 pregnant women had their blood group screened, 168 (7.8%) were Rh negative. Of those with complete clinical data, 72% had blood group O while none had blood group AB. Only 44.4% and 66.7% of the husbands and babies' blood group respectively were documented; 8.3% of the babies were ABO compatible with their mothers. Only 16.7% of the babies appeared to have Rh incompatibility with clinical jaundice although all had negative serial indirect Coomb' test which was done in 55.6% of cases for antibody titre estimation. The mean total and unconjugated bilirubin levels of 64μmol and 54μmol respectively. None had phototherapy or blood transfusion. The mean birth weight and haematocrit were 3.1kg and 45.1% respectively. All deliveries were un-eventful with administration of anti-D immunoglobulin (1500 IU statum dose) documented in 50% of cases given within 72hours of delivery. Conclusion: The prevalence of Rh negativity amongst pregnant women from this study is 7.8%, suggesting that Rh negative blood group is not uncommon in our population. The neonate with incompatible group had mild haemolytic disease indicating good pregnancy outcome. However, adequate counselling is still required in our child-bearing women to prevent morbidity from Rh incompatibility.
[ABSTRACT]   Full text not available  [PDF]
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Unnatural deaths in Benin City Nigeria: Two decades analysis of violent deaths
CC Nwafor, WO Akhiwu, EO Ugiagbe
June 2014, 5(1):41-47
Objective: The aim of this study is to estimate the mortality attributable to violence and trauma and to highlight the need for preventive measures. Method: The records of all accidental, suicidal and homicidal deaths seen in the department of pathology, University of Benin Teaching Hospital, Benin City from January 1990 to December 2009 were reviewed. Result: Unnatural/violent cases accounted for 1,529 (34.1%) of all medicolegal cases within the study period. Accidental deaths accounted for 1,283 (83.9%), homicide 223 (14.6%) and suicide 23 (1.5%) of all unnatural deaths. A total of 1204 males and 325 females were involved in a male to female ratio is 3.7:1. The commonest cause of accidental deaths was road traffic crashes which accounted for 1136 (88.5%) of cases. A total of 1,019 males and 264 females were involved in accidental deaths with a male to female ratio of 3.9:1. Homicidal deaths occurred in 166 males and 57 females. The commonest method of homicide was by use of firearms, which accounted for 154 (69.1%) cases. Suicides were seen in only 23 cases, 19 males and 4 females, in a male to female ratio of 4.8:1. Conclusion: So long as unemployment, poverty and hunger remain with us, violent deaths will continue especially homicides caused by kidnappers. If jobs are available, majority will not resolve to ride motorbikes as source of livelihood. Government should also try to provide better transport system and good roads.
[ABSTRACT]   Full text not available  [PDF]
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Seroprevalence of HIV-1, hepatitis B and C viruses in sickle cell disease patients in Zaria, Nigeria
AA Babadoko, AI Mamman, ZY Aliyu, SA Maude, V Gordeuk, V Sachdev, P Akpanpe, E Attah, Y Suleiman, N Aliyu, J Yusuf, L Mendelsohn, GJ Kato, MT Gladwin
June 2014, 5(1):49-53
Introduction: Transfusion of blood is an important and a frequent modality of treatment for either vaso-occlussive or haemolytic crisis in patients with sickle cell disease (SCD). Sickle cell disease patients are therefore at risk of transfusion transmissible infection,blood transfusion been a recognized route of transmission of HIV, Hepatitis Band C virus particularly in resource constraint settings lacking antigen detection techniques as well as an organized and effective blood transfusion services. Aim: To determine the prevalence of HIV-1, Hepatitis B and C viral antibodies in patients with sickle cell disease. Patients and Method: A cross sectional study of 208 consecutive SCD patients at steady state and 94 healthy non-matched controls were screened for HIV-1antibodies (parallel ELIZA Determine and Uni-Gold), Hepatitis B surface antigen (NOVA) and anti-HCV (NOVA) in 2006. Results: Of the total number of 204 SCD patients screened, 102 (49%) were males and 106 (51%) were females .The mean age of the subjects was 22 ± 8 years. One hundred and nine patients (95.2%) were haemoglobin S homozygote's and 10 (4.8%) were compound heterozygote's for haemoglobin S and C. Ninety percent of the subjects reported less than 5 units of whole blood transfusion during their lifetime. Prevalence of HIV, Hepatitis B and C was 3.9%, 2.0% and 4.4% respectively. Conclusion: Prevalence of HIV, Hepatitis B and C is low in our setting and this may not be unconnected withroutine screening of prospective donors. However increased public awareness, health education programs and better screening techniques will further reduce the spread of these viruses, as other routes of transmission may also play a role.
[ABSTRACT]   Full text not available  [PDF]
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Effects of hyperbilirubinaemia on fructosamine assay in sickle cell anaemia
Isah Adagiri Yahaya
June 2014, 5(1):29-34
Background: Studies have shown that high levels of bilirubin interfere with the colorimetric estimation of fructosamine both in-vivo and invitro. None of the previous studies was conducted in a defined clinical disorder. Aim: The aim of this study was to demonstrate the effects of hyperbilirubinaemia on the measurement of fructosamine in patients with sickle cell anaemia (Hb SS), a highly prevalent genetic disorder in our society. Methodology: Serum fructosamine, glucose, albumin and total bilirubin were measured in 150 Hb SS patients and 100 healthy volunteers as controls. Results: The mean fructosamine concentration was statistically similar in Hb SS patients and controls. No statistical difference was found between the mean fructosamine concentration at different levels of serum total bilirubin in Hb SS patients and controls Conclusion: These results show that high levels of bilirubin in patients with sickle cell anaemia, in the steady state, do not interfere with the colorimetric estimation of fructosamine.
[ABSTRACT]   Full text not available  [PDF]
  489 47 -
Hepatocellular carcinoma in Nigeria - A review
O Ojo, O Okafor, T Ige, DA Ndububa
June 2014, 5(1):19-27
Full text not available  [PDF]
  303 58 -
Elevating the practice of pathology in Nigeria to the 21st century standard
AH Rafindadi
June 2014, 5(1):5-17
Full text not available  [PDF]
  241 56 -