Annals of Tropical Pathology

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 9  |  Issue : 2  |  Page : 126--130

Adenocarcinoma of the prostate: Correlation between serum prostate-specific antigen and Gleason grade group


Murtala Abubakar1, Sani Mohammed Shehu1, Saad Aliyu Ahmed1, Almustapha Aliyu Liman1, Karo Christopher Akpobi1, Ahmed Mohammed2, Umar Mohammed3, Shehu Abdullahi1, Dauda Eneyamire Suleiman1, Balarabe Kabir1 
1 Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State, Nigeria
2 Department of Surgery, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State, Nigeria
3 Department of Pathology, Usman Danfodio University Teaching Hospital, Sokoto, Nigeria

Correspondence Address:
Dr. Murtala Abubakar
Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria - 810 001, Kaduna State
Nigeria

Introduction: Serum prostatic-specific antigen (PSA) concentration determination has established itself as the leading tool in screening for, as well as in estimating the prognosis of, adenocarcinoma of the prostate. This prognostication is usually done in conjunction with the Gleason score and other prognostic indices. The aim of this study was to determine the association between serum PSA concentration and the new (2016 modified) Gleason grade group of tumor among patients with adenocarcinoma of the prostate. Study Design: A retrospective, analytic study. Study Setting: Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria. Study Period: January 2006 to December 2013. Materials and Methods: A total of 211 patients with biopsy-based diagnosis of adenocarcinoma of the prostate were studied. Each of the cases was graded using the (2016 modified) Gleason grading system. Prebiopsy serum PSA concentration in each of the patients was retrieved from either the patient's case records in the Urology Unit of the hospital or from the values filled in by the requesting surgeon. Gleason grade groups of patients were correlated with serum PSA concentration. Results: Gleason grade group 1 was most common in our study with 68 (32.2%) of our patients falling within that category. The study revealed a statistically significant relationship between the serum PSA concentration and the Gleason grade group of cancer (P = 0.00). Conclusion: This study concluded that the serum PSA concentration has a statistically significant association with the Gleason grade group of the tumor in prostatic adenocarcinoma patients. Therefore, patients with high serum PSA concentrations are likely to have high tumor grade group.


How to cite this article:
Abubakar M, Shehu SM, Ahmed SA, Liman AA, Akpobi KC, Mohammed A, Mohammed U, Abdullahi S, Suleiman DE, Kabir B. Adenocarcinoma of the prostate: Correlation between serum prostate-specific antigen and Gleason grade group.Ann Trop Pathol 2018;9:126-130


How to cite this URL:
Abubakar M, Shehu SM, Ahmed SA, Liman AA, Akpobi KC, Mohammed A, Mohammed U, Abdullahi S, Suleiman DE, Kabir B. Adenocarcinoma of the prostate: Correlation between serum prostate-specific antigen and Gleason grade group. Ann Trop Pathol [serial online] 2018 [cited 2020 Nov 30 ];9:126-130
Available from: https://www.atpjournal.org/article.asp?issn=2251-0060;year=2018;volume=9;issue=2;spage=126;epage=130;aulast=Abubakar;type=0