• Users Online: 565
  • Print this page
  • Email this page
CASE REPORT
Year : 2019  |  Volume : 10  |  Issue : 2  |  Page : 172-174

Epstein–Barr virus-positive diffuse large B-cell lymphoma, not otherwise specified: A diagnostic challenge


Department of Pathology, Maulana Azad Medical College, Delhi, India

Correspondence Address:
Dr. Sarika Singh
Department of Pathology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, Delhi - 110 002
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/atp.atp_31_19

Get Permissions

Epstein–Barr virus-positive diffuse large B-cell lymphoma, not otherwise specified (EBV + DLBCL) is a new separate entity included in 2016 WHO classification with dismal prognosis. Hence, awareness is needed for prompt diagnosis and swift treatment. Here, we present a case of a 48-year-old male with multiple cervical lymphadenopathy for 5 months. On examination, the patient had severe pallor and multiple firm to hard nontender cervical lymph nodes. Bone marrow aspiration was a dry tap. Bone marrow biopsy revealed nodular collection of atypical monomorphic lymphoid cells admixed with lymphocytes, eosinophils, and plasma cells in the background. Lymph node biopsy demonstrated total effacement of normal lymph node architecture with atypical lymphoid cells. These cells were positive for CD20, CD30, and CD38, LMP1, myc, IRF4/MUM1, and FOXP1 and were negative for anaplastic lymphoma kinase, CD3, CD10, bcl2, bcl6, and CD15. Diagnosis of EBV-positive DLBCL was rendered.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed170    
    Printed10    
    Emailed0    
    PDF Downloaded28    
    Comments [Add]    

Recommend this journal